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HCMArticle from Uni Klinik Giessen 06.02.2008New to the HCM Gentest of the medicel small animal hospital of the Ludwig Maximilians universty in munchin was accomplished a study to two gene test on HCM,availale in germany,with maine Coons.The result shwos that the gene test does not bring anythimg.The study resulted in that Maine Coons with HCM are just as frequently positively tested in the gene test,as Maine Coons without HCM.Therefore the investment is not worthwhile itself into a gene test simply.In the folling one we printed the result of the study,which was presented om the last weekend in the context of a lecture on a specialized congress for the animal medical profession in pouring.genetic association of the A31P-andA74T-Polymorphismen with the felinen hypertrophen Kardiomyopathie wlth the Maine Coon C.Schinner,K Weber,K.Hartmann,G.Wess,abteilung for Kardiologie of the medical small animal of the Ludwig Maximilians university Munich introduction:The hypertrophe Kardiomyopathie (HCM) is the mostfrequent feline heart illness with autosomal dominantemhereditary course and varying Penetranz.The A31P-and A74T-Polymorphismen (SNPs) in the kardialen Myosin benig thing protein C3-Gen(MYBPC§) are regarded at present as causal mutations with Maine Coon cats.In practice ultrasonic diagnoses devitiatefrequently from the Genotyp.From breed as well as verterinary side is unclear,how with heart-healthy genotyp cats will proceed are.A goal of the study were therefore the evalution of the clinical association of both SNPs as well as the evaluation of the clinical validity of gene tests already marketed.material and methods:83 Maine Coon cats and 68 cats of different races entered study.Female animals had to be older as 36 months,older than 24 months.The phenotyp"heart-healthy"or"HCM" had to be clear to assign.ThePhaenotypisierung took place by means of heart ultrasonic,the Genotypisierung by means of tapman r Genotyping Asssays.Results:21,13% of the heart-healthy animal were positve in the gene test forthe A31P_and 32,84% for the A74T-SNP.75% of the HCM group carried the healthy allele concerning the A31P-and 50% concerning the A74T-SNPs.The allele frequencies did not differ between the groups ofphenotypes significantly.On the basis the available study population no reference existed that gene test already marketed prossess a praediktiven value.A computer-assisted protein analysis arranged the effect of the SNPs on the protein as beigne.The A31P Polymorphismus occurs also at other cat races.Conclusions:With the examimed patient number no association was found between theHCM and the examined Polymorphismen.The gold standard for the breed selection exists further in the annual echokardiographischen investigation.

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